A Clinical Investigation Using Quantitative Light-Induced Fluorescence (QLF) of the Anticaries Efficacy of a Dentifrice Containing 1.5% Arginine

A Clinical Investigation Using Quantitative Light-Induced Fluorescence (QLF) of the Anticaries Efficacy of a Dentifrice Containing 1.5% Arginine and 1450 ppm Fluoride as Sodium Monofluorophosphate.

The Journal of Clinical Dentistry (ISSN 0895-8831) is published by Professional Audience Communications, Inc., P.O. Box 243, Yardley, PA 19067. POSTMASTER; Send address change to P.O. Box 243, Yardley, PA 19067.

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• Objective: The purpose of this study was to assess the ability of a new dentifrice containing arginine, an insoluble calcium compound, and fluoride to arrest or reverse naturally occurring buccal caries lesions measured using Quantitative Light-induced Fluorescence (QLF).
• Methods: Three study groups used dentifrices which contained 1) 1.5% arginine and 1450 ppm fluoride as sodium monofluo- rophosphate (experimental), 2) 1450 ppm fluoride as sodium monofluorophosphate (positive control), and 3) no fluoride (negative control). All three dentifrices were formulated in the same calcium base. The study participants were from three schools in the city of Chengdu, Sichuan Province, China. A total of 446 of 450 recruited subjects completed the study. Of these, 147 were in the experi- mental, 148 in the positive control, and 151 in the negative control groups. The initial age of the children was 10–12 years (mean 11.4 ± 0.54); 47.5% were female.
• Results: Using QLF, assessments of buccal caries lesions were made at baseline and after three and six months of product use. For DQ, representing lesion volume, the baseline mean value for the three groups was 27.30, and at the three-month examination the mean values were 16.76, 19.25, and 25.89 for the experimental, positive, and negative control dentifrices, respectively. This represents improvements from baseline of 38.6%, 29.5%, and 5.2%. At six months, the DQ values for the three groups were 13.46, 18.47, and 24.18, representing improvements from baseline of 50.7%, 32.3%, and 11.4%.

(J Clin Dent 2013;24[Spec Iss A]:15–22)